"RISE" - Use of electrical stimulation to restore standing in paraplegics with longterm denervated degenerated muscles DDM

A novel clinical rehabilitation method for patients who have permanent and non-recoverable muscle denervation in the legs has been developed. The technique based on Functional Electrical Stimulation (FES) restores muscle tissue, muscle function and the ability to rise in these severely disabled patients. Such an improvement in mobility leads to a substantial reduction in the risk and severity of bed sores and other secondary medical problems, resulting in less frequent hospitalisation and a reduced burden on public health services, as well as improvements in the patient's quality of life.

Stimulation devices:

Bench Stimulator 2 channel stimulator Stimulette den2x
stimulator for laboratory experiments 2-channel custom build battery driven Stimulator used in the clinical study from research to industry - after study completion our results finally lead to a commercial available stimulator Schuhfried Stimulette den2x

Recommended training parameters:

poster of training parameters

Poster presented at the Spring Padua Muscle Days
Terme Euganee, Padua (Italy), March 15 - 17, 2013

JPG - A4, 300dpi (1,5MB)
- A3, 300dpi (2,4MB)
PDF - A4, 600dpi (1,3MB)

Löfler S, Mayr W, Mödlin M et al. FES training protocols for the functional recovery of permanent complete denervated human muscles [v1; not peer reviewed]. F1000Research 2015, 4:436 (poster) (doi: 10.7490/f1000research.1110189.1)

Top Publications:

Home-based Functional Electrical Stimulation (h-bFES) rescues permanently denervated muscles in paraplegic patients with complete lower motor neuron lesion
Kern, Carraro, Adami, Biral, Hofer, Forstner, Mödlin, Vogelauer, Pond, Boncompagni, Paolini, Mayr, Protasi, Zampieri
Neurorehabil Neural Repair. 2010 Oct; 24(8):709-21. Epub 2010 May 11.

One Year of Home-based Functional Electrical Stimulation (FES) in Complete Lower Motor Neuron Paraplegia: Recovery of Tetanic Contractility Drives the Structural Improvements of Denervated Muscle.
Kern H, Carraro U, Adami N, Biral D, Hofer C, Loefler S, Vogelauer M, Mayr W, Rupp R, Zampieri S.
Neurol Res. 2010 Feb;32(1):5-12

Structural differentiation of skeletal muscle fibers in absence of innervation in humans.
Boncompagni S, Kern H, Rossini K, Hofer C, Mayr W, Carraro U, Protasi F.
Proc Natl Acad Sci USA. 2007; 104(49): 19339-19344.

Long-term denervation in humans causes degeneration of both contractile and excitation-contraction coupling apparatus which is reversible by functional electrical stimulation (FES): A role for myofiber regeneration?
Kern H, Boncompagni S, Rossini K, Mayr W, Fanò G, Zanin ME, Podhorska-Okolow M, Protasi F, Carraro U.
Journal of Neuropathology & Experimental Neurology. 2004; 63: 919-931.